Brugia pahangi infections in immune-compromised rats demonstrate that separate mechanisms control adult worm and microfilarial numbers.
Identifieur interne : 00D160 ( Main/Exploration ); précédent : 00D159; suivant : 00D161Brugia pahangi infections in immune-compromised rats demonstrate that separate mechanisms control adult worm and microfilarial numbers.
Auteurs : R. Lawrence [Royaume-Uni] ; D A DenhamSource :
- Parasite immunology [ 0141-9838 ] ; 1992.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (analyse), Brugia pahangi (immunologie), Ciclosporine (administration et posologie), Cyclophosphamide (administration et posologie), Filariose lymphatique (immunologie), Filariose lymphatique (parasitologie), Immunoglobuline G (analyse), Immunoglobuline M (analyse), Interactions hôte-parasite, Mâle, Rat nude, Rats, Sujet immunodéprimé (immunologie).
- MESH :
- administration et posologie : Ciclosporine, Cyclophosphamide.
- analyse : Anticorps antihelminthe, Immunoglobuline G, Immunoglobuline M.
- immunologie : Brugia pahangi, Filariose lymphatique, Sujet immunodéprimé.
- parasitologie : Filariose lymphatique.
- Animaux, Interactions hôte-parasite, Mâle, Rat nude, Rats.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (analysis), Brugia pahangi (immunology), Cyclophosphamide (administration & dosage), Cyclosporine (administration & dosage), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (parasitology), Host-Parasite Interactions, Immunocompromised Host (immunology), Immunoglobulin G (analysis), Immunoglobulin M (analysis), Male, Rats, Rats, Nude.
- MESH :
- chemical , administration & dosage : Cyclophosphamide, Cyclosporine.
- chemical , analysis : Antibodies, Helminth, Immunoglobulin G, Immunoglobulin M.
- immunology : Brugia pahangi, Elephantiasis, Filarial, Immunocompromised Host.
- parasitology : Elephantiasis, Filarial.
- Animals, Host-Parasite Interactions, Male, Rats, Rats, Nude.
Abstract
The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% recovery in athymic rats. CsA and Cy treated rats did not have increased adult worm burdens. Microfilarial (Mf) levels (expressed as Mf per ml per adult worm) were highly elevated in both athymic and Cy treated rats but not in CsA treated rats. IgG and IgM levels to B. pahangi antigens were severely depressed in both athymic and Cy treated rats. IgG levels but not IgM levels were abrogated in CsA treated rats. These results implied that control of larval establishment or adult killing, and regulation of Mf levels are separate T-cell dependent mechanisms and act independently of IgG antibody. Control of Mf levels is associated with a specific IgM response which is Cy sensitive but CsA resistant.
PubMed: 1437230
Affiliations:
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Le document en format XML
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Lawrence</name><affiliation wicri:level="1"><nlm:affiliation>London School of Hygiene and Tropical Medicine, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1437230</idno><idno type="pmid">1437230</idno><idno type="wicri:Area/PubMed/Corpus">005915</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005915</idno><idno type="wicri:Area/PubMed/Curation">005915</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005915</idno><idno type="wicri:Area/PubMed/Checkpoint">005915</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005915</idno><idno type="wicri:Area/Ncbi/Merge">001647</idno><idno type="wicri:Area/Ncbi/Curation">001647</idno><idno type="wicri:Area/Ncbi/Checkpoint">001647</idno><idno type="wicri:doubleKey">0141-9838:1992:Lawrence R:brugia:pahangi:infections</idno><idno type="wicri:Area/Main/Merge">00DC50</idno><idno type="wicri:Area/Main/Curation">00D160</idno><idno type="wicri:Area/Main/Exploration">00D160</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Brugia pahangi infections in immune-compromised rats demonstrate that separate mechanisms control adult worm and microfilarial numbers.</title><author><name sortKey="Lawrence, R" sort="Lawrence, R" uniqKey="Lawrence R" first="R" last="Lawrence">R. Lawrence</name><affiliation wicri:level="1"><nlm:affiliation>London School of Hygiene and Tropical Medicine, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Hygiene and Tropical Medicine</wicri:regionArea></affiliation></author><author><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></author></analytic><series><title level="j">Parasite immunology</title><idno type="ISSN">0141-9838</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (analysis)</term><term>Brugia pahangi (immunology)</term><term>Cyclophosphamide (administration & dosage)</term><term>Cyclosporine (administration & dosage)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Host-Parasite Interactions</term><term>Immunocompromised Host (immunology)</term><term>Immunoglobulin G (analysis)</term><term>Immunoglobulin M (analysis)</term><term>Male</term><term>Rats</term><term>Rats, Nude</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (analyse)</term><term>Brugia pahangi (immunologie)</term><term>Ciclosporine (administration et posologie)</term><term>Cyclophosphamide (administration et posologie)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Immunoglobuline G (analyse)</term><term>Immunoglobuline M (analyse)</term><term>Interactions hôte-parasite</term><term>Mâle</term><term>Rat nude</term><term>Rats</term><term>Sujet immunodéprimé (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cyclophosphamide</term><term>Cyclosporine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Ciclosporine</term><term>Cyclophosphamide</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term><term>Immunoglobuline M</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia pahangi</term><term>Filariose lymphatique</term><term>Sujet immunodéprimé</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia pahangi</term><term>Elephantiasis, Filarial</term><term>Immunocompromised Host</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Host-Parasite Interactions</term><term>Male</term><term>Rats</term><term>Rats, Nude</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Interactions hôte-parasite</term><term>Mâle</term><term>Rat nude</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The immunological basis of resistance to Brugia pahangi infection in rats was studied. Infections were investigated in athymic rnu/rnu rats and in rats treated with the immuno-suppressive agents cyclosporin A (CsA) or cyclophosphamide (Cy). The recovery of adult worms in normal rats was 1-2% in comparison to 12.2% recovery in athymic rats. CsA and Cy treated rats did not have increased adult worm burdens. Microfilarial (Mf) levels (expressed as Mf per ml per adult worm) were highly elevated in both athymic and Cy treated rats but not in CsA treated rats. IgG and IgM levels to B. pahangi antigens were severely depressed in both athymic and Cy treated rats. IgG levels but not IgM levels were abrogated in CsA treated rats. These results implied that control of larval establishment or adult killing, and regulation of Mf levels are separate T-cell dependent mechanisms and act independently of IgG antibody. Control of Mf levels is associated with a specific IgM response which is Cy sensitive but CsA resistant.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country></list><tree><noCountry><name sortKey="Denham, D A" sort="Denham, D A" uniqKey="Denham D" first="D A" last="Denham">D A Denham</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Lawrence, R" sort="Lawrence, R" uniqKey="Lawrence R" first="R" last="Lawrence">R. Lawrence</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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